2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-108909
    Chymopapain 9001-09-6
    Chymopapain is a non-specific proteo-glycanase derived from the papaya plant. Chymopapain directly into the intervertebral disc caused disc narrowing due to dissolution of the extruded material. Chymopapain has the potential for the research of herniated lumbar discs.
    Chymopapain
  • HY-110122
    AZ 12216052 1290628-31-7 ≥98.0%
    AZ 12216052 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect.
    AZ 12216052
  • HY-110176
    ASP2535 374886-51-8 ≥99.0%
    ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease.
    ASP2535
  • HY-110278
    ADX71743 1431641-29-0 99.30%
    ADX71743 is a highly selective, noncompetitive and brain-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM). ADX71743 has anxiolytic-like activity.
    ADX71743
  • HY-111217
    AKOS-22 878983-38-1 99.23%
    AKOS-22 is a potent mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor (Kd=15.4 μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects against mitochondrial dysfunction.
    AKOS-22
  • HY-111262
    ABT-384 868623-40-9 99.85%
    ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. ABT-384 exhibits high affinity (Ki 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer’s disease (AD).
    ABT-384
  • HY-112388
    GSK-3b Inhibitor XI 626604-39-5 99.10%
    GSK-3b Inhibitor XI (Compound 33) is a potent and selective GSK3β inhibitor, with a Ki value of 25 nM. GSK-3b Inhibitor XI increases glycogen synthase (GS) activity. GSK-3b Inhibitor XI can be used for research on type 2 diabetes and Alzheimer’s disease.
    GSK-3b Inhibitor XI
  • HY-112855
    PF-06454589 1527473-30-8 99.91%
    PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively. PF-06447475 can be used for parkinson's disease (PD) research.
    PF-06454589
  • HY-113951
    Prolyl Endopeptidase Inhibitor 1 86925-97-5
    Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect.
    Prolyl Endopeptidase Inhibitor 1
  • HY-115681
    (2R/S)-6-PNG 68682-01-9 ≥99.0%
    (2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Cav3.2 T-type Ca2+ channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice.
    (2R/S)-6-PNG
  • HY-115719
    CASK-IN-1 2755241-73-5 99.7%
    CASK-IN-1 (compound 26) is a highly potent and selective CASK inhibitor (Kd of 22 nM).
    CASK-IN-1
  • HY-116193
    5-PAHSA 1481636-41-2 98.08%
    5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics.
    5-PAHSA
  • HY-116535
    D-threo-PPMP hydrochloride 139889-65-9 ≥98.0%
    D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production.
    D-threo-PPMP hydrochloride
  • HY-116622
    α5IA 215874-86-5
    α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential.
    α5IA
  • HY-116699
    CP-868388 free base 702681-67-2 99.66%
    CP-868388 free base is a potent, selective and orally active PPARα agonist with a Ki value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (Ki of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions.
    CP-868388 free base
  • HY-117073
    ITH12575 1802013-08-6 99.14%
    ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations.
    ITH12575
  • HY-117348
    NCC-149 1316652-41-1 99.14%
    NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research.
    NCC-149
  • HY-118994
    ARN19874 2190502-57-7 99.54%
    ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor with an IC50 of ~34 μM.
    ARN19874
  • HY-119541
    Ampreloxetine 1227056-84-9 98.49%
    Ampreloxetine (TD-9855) is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension.
    Ampreloxetine
  • HY-120294
    Chrysin 6-C-glucoside 8-C-arabinoside 185145-34-0 99.11%
    Chrysin 6-C-glucoside 8-C-arabinoside can inhibit the CGRP releasing and the activation of TRPV1 channel. Chrysin 6-C-glucoside 8-C-arabinoside can be used for anti-migraine research.
    Chrysin 6-C-glucoside 8-C-arabinoside
Cat. No. Product Name / Synonyms Application Reactivity